Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivity.
Identifieur interne : 000066 ( France/Analysis ); précédent : 000065; suivant : 000067Parkinson's disease patients show reduced cortical-subcortical sensorimotor connectivity.
Auteurs : Michael Sharman [France] ; Romain Valabregue ; Vincent Perlbarg ; Linda Marrakchi-Kacem ; Marie Vidailhet ; Habib Benali ; Alexis Brice ; Stephane LehéricySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Basal Ganglia (pathology), Basal Ganglia (physiopathology), Brain Mapping (methods), Cerebral Cortex (pathology), Cerebral Cortex (physiopathology), Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neural Pathways (pathology), Neural Pathways (physiopathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology).
- MESH :
- methods : Brain Mapping, Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Basal Ganglia, Cerebral Cortex, Neural Pathways, Parkinson Disease.
- physiopathology : Basal Ganglia, Cerebral Cortex, Neural Pathways, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Reduced dopamine input to cortical and subcortical brain structures, particularly those in the sensorimotor network, is a hallmark of Parkinson's disease (PD). The extent to which dopamine dysfunction affects connectivity within this and other brain networks remains to be investigated. The purpose of this study was to measure anatomical and functional connectivity in groups of PD patients and controls to determine whether connectivity deficits within the cortico-basal ganglia thalamocortical system could be attributed to PD, particularly in sensorimotor connections. A neuroimaging paradigm involving diffusion-weighted magnetic resonance imaging (MRI) and resting-state functional MRI was implemented in a large cohort of PD patients and control subjects. Probabilistic tractography and functional correlation analyses were performed to map connections between brain structures and to derive indices of connectivity that were then used to compare groups. Anatomical connectivity deficits were demonstrated in PD patients, specifically for sensorimotor connections. Functional deficits were also found in some of the same connections. In addition, functional connectivity was found to increase in associative and limbic connections in PD patients compared with controls. This study lends support to findings regarding the dysfunction of the sensorimotor circuit in PD. As deficits in anatomical and functional connectivity within this circuit were in some cases concordant in PD patients, a possible link between brain structure and function is suggested. Increases in functional connectivity in other cortico-basal ganglia thalamocortical circuits may be indicative of compensatory effects in response to system deficits elsewhere.
Url:
DOI: 10.1002/mds.25255
PubMed: 23144002
Affiliations:
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pubmed:23144002Le document en format XML
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cortical-subcortical sensorimotor connectivity.</title><author><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name><affiliation wicri:level="1"><nlm:affiliation>UMR-S975, CRICM-INSERM-UPMC Paris 6, Paris, Île-de-France, France. michael.sharman@etu.upmc.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR-S975, CRICM-INSERM-UPMC Paris 6, Paris, Île-de-France</wicri:regionArea><wicri:noRegion>Île-de-France</wicri:noRegion><wicri:noRegion>Île-de-France</wicri:noRegion></affiliation></author><author><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name></author><author><name sortKey="Perlbarg, Vincent" sort="Perlbarg, Vincent" uniqKey="Perlbarg V" first="Vincent" last="Perlbarg">Vincent Perlbarg</name></author><author><name sortKey="Marrakchi Kacem, Linda" sort="Marrakchi Kacem, Linda" uniqKey="Marrakchi Kacem L" first="Linda" last="Marrakchi-Kacem">Linda Marrakchi-Kacem</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" 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scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Cerebral Cortex</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="mix" xml:lang="tl"><term>MRI</term><term>Parkinson's disease</term><term>basal ganglia</term><term>diffusion imaging</term><term>fMRI</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reduced dopamine input to cortical and subcortical brain structures, particularly those in the sensorimotor network, is a hallmark of Parkinson's disease (PD). The extent to which dopamine dysfunction affects connectivity within this and other brain networks remains to be investigated. The purpose of this study was to measure anatomical and functional connectivity in groups of PD patients and controls to determine whether connectivity deficits within the cortico-basal ganglia thalamocortical system could be attributed to PD, particularly in sensorimotor connections. A neuroimaging paradigm involving diffusion-weighted magnetic resonance imaging (MRI) and resting-state functional MRI was implemented in a large cohort of PD patients and control subjects. Probabilistic tractography and functional correlation analyses were performed to map connections between brain structures and to derive indices of connectivity that were then used to compare groups. Anatomical connectivity deficits were demonstrated in PD patients, specifically for sensorimotor connections. Functional deficits were also found in some of the same connections. In addition, functional connectivity was found to increase in associative and limbic connections in PD patients compared with controls. This study lends support to findings regarding the dysfunction of the sensorimotor circuit in PD. As deficits in anatomical and functional connectivity within this circuit were in some cases concordant in PD patients, a possible link between brain structure and function is suggested. Increases in functional connectivity in other cortico-basal ganglia thalamocortical circuits may be indicative of compensatory effects in response to system deficits elsewhere.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><name sortKey="Marrakchi Kacem, Linda" sort="Marrakchi Kacem, Linda" uniqKey="Marrakchi Kacem L" first="Linda" last="Marrakchi-Kacem">Linda Marrakchi-Kacem</name><name sortKey="Perlbarg, Vincent" sort="Perlbarg, Vincent" uniqKey="Perlbarg V" first="Vincent" last="Perlbarg">Vincent Perlbarg</name><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></noCountry><country name="France"><noRegion><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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